Job Description: Scientist II, Discovery Science

We leverage our computational platform to identify promising drug candidates, validate and de-risk them through preclinical studies, and progress remaining candidates to the clinic through industry and investor partnerships. We have established collaborations with leading biopharmaceutical companies and are now scaling the business and building our internal drug pipeline. twoXAR is venture-backed with financing from SoftBank Ventures and Andreessen Horowitz and has strong ties to Stanford University and MIT. Our management team and advisory board have decades of biopharmaceutical management experience, built software systems used by tens of millions of people, held VP and C-level positions at Fortune 100 companies, and have had previous startups end with successful strategic acquisitions.

• Utilize our proprietary AI-driven software to rapidly build computational disease models.  This includes:
  • inspecting and annotating disease-specific biomedical data (e.g. omics, EMR, and clinical trials data)
  • using our AI-augmented annotation processes to properly define our disease of interest
  • running and carefully evaluating the results of our analysis algorithms
• Examine and prioritize predicted drug discovery hits identified by our proprietary, AI-platform in a range of diseases, including oncology, immunology, and fibrosis.
• Perform extensive literature and data review of drug discovery hits:
  • investigate potential mechanisms specific to the disease of interest
  • compare MoAs to preclinically or clinically tested MoAs to evaluate novelty
  • evaluate DMPK data to verify a molecule’s suitability for preclinical testing
• Effectively communicate (written and verbal) and defend research internally

• Understanding of pharmacology, cellular biology, and omics is required
• Exquisite and demonstrated attention to detail is a must to be successful in this role
• Prior experience in a pharmaceutical R&D environment is a very significant plus
• No computational experience is necessary, though familiarity with big data and bioinformatics is a plus
• Demonstrated ability to rapidly learn new concepts
• Full-time, on-site availability in Mountain View

• PhD, MD, or PharmD (complete or late-stage candidate)
• 5+ years of independent biomedical research
• Startup minded: high energy, low maintenance, self-starter that is comfortable in a fast-paced environment
• Cultural fit: genuine, collaborative, innovative, data-driven, and goal-oriented

twoXAR is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.